GUANGZHOU,May7(Xinhua)--AteamofChinesecancerresearchershasuncoveredanovelmechanismthroughwhichobesity-relatedmicrobesinone'sgutcanpromotecancerprogression.Itinvolvesthereleaseofspecificchemicalsthatcanhaveasignificantimpactonthegrowthandspreadofcancercells.Ahigh-fatdiet(HFD)iswidelyconsideredasignificantriskfactorforthemalignantprogressionofvariouscancers,largelyduetoitsdisruptiveeffectsonintestinalmicrobiota.However,thepreciseroleofHFDinthedevelopmentofcancerwaspreviouslynotfullyunderstood.TheresearchersfromSunYat-senUniversityestablishedmultiplemodelsincancer-bearingmiceandfoundthatfat-nurturedmicrobiotareleasedabundantleucine,anaminoacidfoundinmanyproteins.Anelevatedleucinelevelinperipheralbloodhasbeenfoundtobeassociatedwithpoorclinicaloutcomesinfemalepatientswithbreastcancer,accordingtoastudypublishedonMondayinthejournalProceedingsoftheNationalAcademyofSciencesoftheUnitedStates.Inaddition,abnormalgutmicrobiotaareimplicatedinthedevelopmentofresistancetochemotherapyandsomeimmunetherapiesforbreastcancer,lungcancer,andmelanoma.Thefindingsofthisstudyopenabroadavenueforanticancertherapeuticstrategiesbytargetingtheaberrantmetabolismofgutmicrobiota,theresearcherssaid.Editor:DisclaimerTheviewsandopinionsexpressedinthisarticlearethoseoftheauthor's,GMW.cnmakesnorepresentationsastoaccuracy,suitability,orvalidityofanyinformationonthissiteandwillnotbeliableforanyerrors,omissions,ordelaysinthisinformation.